Version 5.4
Homo sapiens Gene: POU2F1
Summary
InnateDB Gene IDBG-104534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU2F1
Gene Name POU class 2 homeobox 1
Synonyms oct-1B; OCT1; OTF1
Species Homo sapiens
Ensembl Gene ENSG00000143190
Encoded Proteins
IDBP-104536
POU class 2 homeobox 1
IDBP-104544
POU class 2 homeobox 1
IDBP-104546
POU class 2 homeobox 1
IDBP-389487
POU class 2 homeobox 1
IDBP-389488
POU class 2 homeobox 1
IDBP-389489
POU class 2 homeobox 1
IDBP-389490
POU class 2 homeobox 1
IDBP-596241
POU class 2 homeobox 1
IDBP-585188
POU class 2 homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:167220829-167427345
Strand Forward strand
Band q24.2
Transcripts
ENST00000367866 ENSP00000356840
ENST00000367865
ENST00000367862 ENSP00000356836
ENST00000271411 ENSP00000271411
ENST00000442313 ENSP00000404571
ENST00000429375 ENSP00000401217
ENST00000420254 ENSP00000414660
ENST00000443275 ENSP00000415993
ENST00000492850
ENST00000470928
ENST00000490100
ENST00000559038
ENST00000557909
ENST00000560232 ENSP00000453094
ENST00000541643 ENSP00000441285
ENST00000559648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 81 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0010467 gene expression
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026565
View Gene Order
ENSBTAG00000024534
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
atf2_pathway
ATF-2 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
ar_tf_pathway
Regulation of Androgen receptor activity
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.283402 Hs.599861 Hs.617075
RefSeq NM_001198783 NM_001198786 NM_002697
HUGO
OMIM
CCDS CCDS1259 CCDS55655 CCDS55656
HPRD 01250
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca