InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD63

Summary

InnateDB Protein

IDBP-38976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD63

Protein Name

CD63 molecule

Synonyms

LAMP-3; ME491; MLA1; OMA81H; TSPAN30;

Species

Homo sapiens

Ensembl Protein

ENSP00000257857

InnateDB Gene

IDBG-38974 (CD63)

Protein Structure

UniProt Annotation

Function

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269PubMed:16917503, ECO:0000269PubMed:21803846, ECO:0000269PubMed:21962903, ECO:0000269PubMed:23632027, ECO:0000269PubMed:24635319}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.

Disease Associations

Tissue Specificity

Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. {ECO:0000269PubMed:19640571}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0002576	platelet degranulation
GO:0007160	cell-matrix adhesion
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0016477	cell migration
GO:0030168	platelet activation
GO:0034613	cellular protein localization
GO:0035646	endosome to melanosome transport
GO:0045087	innate immune response (InnateDB)
GO:0048757	pigment granule maturation
GO:1900746	regulation of vascular endothelial growth factor signaling pathway
GO:2000680	regulation of rubidium ion transport
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0031088	platelet dense granule membrane
GO:0031226	intrinsic component of plasma membrane
GO:0031902	late endosome membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0097487	multivesicular body, internal vesicle