InnateDB Protein
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IDBP-389803.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TSEN15
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Protein Name
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tRNA splicing endonuclease 15 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402002
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InnateDB Gene
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IDBG-105345 (TSEN15)
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Protein Structure
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Function |
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269PubMed:15109492}.
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Subcellular Localization |
Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in testis and uterus. {ECO:0000269PubMed:11318611}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000213
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tRNA-intron endonuclease activity
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Biological Process |
GO:0006388
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tRNA splicing, via endonucleolytic cleavage and ligation
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GO:0006397
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mRNA processing
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GO:0090502
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RNA phosphodiester bond hydrolysis, endonucleolytic
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Cellular Component |
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PDB ID |
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InterPro |
IPR018593
tRNA-splicing endonuclease subunit Sen15
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PFAM |
PF09631
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WW01
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PhosphoSite |
PhosphoSite-Q8WW01
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
116461
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UniGene |
Hs.705867
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RefSeq |
NP_001120866
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HUGO |
HGNC:16791
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OMIM |
608756
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CCDS |
CCDS44286
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HPRD |
12292
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IMGT |
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EMBL |
AF288394
AK296655
AL157943
AL158011
BC022030
CH471067
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GenPept |
AAG60614
AAH22030
BAG59252
EAW91174
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