Homo sapiens Gene: TSEN15
Summary
InnateDB Gene IDBG-105345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSEN15
Gene Name tRNA splicing endonuclease 15 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198860
Encoded Proteins
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary tRNA splicing is a fundamental process required for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004 [PubMed 15109492]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:184051677-184074212
Strand Forward strand
Band q25.3
Transcripts
ENST00000361641 ENSP00000355299
ENST00000367518
ENST00000423085 ENSP00000402002
ENST00000457455
ENST00000485209 ENSP00000435144
ENST00000462677 ENSP00000432397
ENST00000533373 ENSP00000436996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 116461
UniGene Hs.548197 Hs.705867
RefSeq NM_001127394 NM_001300764 NM_001300766 NM_052965 XM_006711150
HUGO HGNC:16791
OMIM 608756
CCDS CCDS1361 CCDS44286 CCDS72993
HPRD 12292
IMGT
EMBL
GenPept
RNA Seq Atlas 116461