InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF6

Summary

InnateDB Protein

IDBP-389995.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF6

Protein Name

interferon regulatory factor 6

Synonyms

LPS; OFC6; PIT; PPS; PPS1; VWS; VWS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000403855

InnateDB Gene

IDBG-106452 (IRF6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	14 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0045087	innate immune response (InnateDB)

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001346 Interferon regulatory factor DNA-binding domain
IPR008984 SMAD/FHA domain
IPR019471 Interferon regulatory factor-3

PFAM

PF00605
PF10401

PRINTS

PR00267

PIRSF

SMART

SM00348

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AL022398

GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca