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InnateDB Protein
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IDBP-390000.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HHAT
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Protein Name
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hedgehog acyltransferase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000413399
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InnateDB Gene
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IDBG-106475 (HHAT)
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Protein Structure
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| Function |
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (By similarity). May bind GTP. {ECO:0000250}.
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| Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitously expressed in normal tissues and cancer cell lines. {ECO:0000269PubMed:11160356}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
2
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
IPR004299
Membrane bound O-acyl transferase, MBOAT
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| PFAM |
PF03062
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q5VTY9
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
55733
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| UniGene |
Hs.58650
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| RefSeq |
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| HUGO |
HGNC:18270
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| OMIM |
605743
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| CCDS |
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| HPRD |
12041
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4