InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GDF11

Summary

InnateDB Protein

IDBP-39059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GDF11

Protein Name

growth differentiation factor 11

Synonyms

BMP-11; BMP11;

Species

Homo sapiens

Ensembl Protein

ENSP00000257868

InnateDB Gene

IDBG-39057 (GDF11)

Protein Structure

UniProt Annotation

Function

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0007399	nervous system development
GO:0007498	mesoderm development
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0021512	spinal cord anterior/posterior patterning
GO:0031016	pancreas development
GO:0040007	growth
GO:0045596	negative regulation of cell differentiation
GO:0048469	cell maturation
GO:0048593	camera-type eye morphogenesis
GO:0060021	palate development