InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCRIB

Summary

InnateDB Protein

IDBP-39071.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCRIB

Protein Name

scribbled homolog (Drosophila)

Synonyms

CRIB1; SCRB1; SCRIB1; Vartul;

Species

Homo sapiens

Ensembl Protein

ENSP00000366756

InnateDB Gene

IDBG-39063 (SCRIB)

Protein Structure

UniProt Annotation

Function

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. {ECO:0000269PubMed:15182672, ECO:0000269PubMed:15775968, ECO:0000269PubMed:16344308, ECO:0000269PubMed:16965391, ECO:0000269PubMed:18641685, ECO:0000269PubMed:18716323, ECO:0000269PubMed:19041750}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1- dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.

Disease Associations

Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269PubMed:22095531}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level). {ECO:0000269PubMed:15806148}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0001921	positive regulation of receptor recycling
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0032863	activation of Rac GTPase activity
GO:0035089	establishment of apical/basal cell polarity
GO:0043065	positive regulation of apoptotic process
GO:0045930	negative regulation of mitotic cell cycle
GO:0050918	positive chemotaxis
GO:0060561	apoptotic process involved in morphogenesis
GO:0060603	mammary gland duct morphogenesis
GO:0071896	protein localization to adherens junction

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0030027	lamellipodium
GO:0031252	cell leading edge
GO:0034750	Scrib-APC-beta-catenin complex
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome