Version 5.4
Homo sapiens Gene: SCRIB
Summary
InnateDB Gene IDBG-39063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCRIB
Gene Name scribbled homolog (Drosophila)
Synonyms CRIB1; SCRB1; SCRIB1; Vartul
Species Homo sapiens
Ensembl Gene ENSG00000180900
Encoded Proteins
IDBP-39067
scribbled homolog (Drosophila)
IDBP-39069
scribbled homolog (Drosophila)
IDBP-39071
scribbled homolog (Drosophila)
IDBP-591468
scribbled homolog (Drosophila)
IDBP-590850
scribbled homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143790920-143815379
Strand Reverse strand
Band q24.3
Transcripts
ENST00000320476 ENSP00000322938
ENST00000356994 ENSP00000349486
ENST00000377533 ENSP00000366756
ENST00000531163
ENST00000525051
ENST00000526832 ENSP00000431519
ENST00000546337
ENST00000531942 ENSP00000433546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0001921 positive regulation of receptor recycling
GO:0002093 auditory receptor cell morphogenesis
GO:0008105 asymmetric protein localization
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0016080 synaptic vesicle targeting
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
GO:0021747 cochlear nucleus development
GO:0032863 activation of Rac GTPase activity
GO:0035089 establishment of apical/basal cell polarity
GO:0042060 wound healing
GO:0043065 positive regulation of apoptotic process
GO:0043615 astrocyte cell migration
GO:0045930 negative regulation of mitotic cell cycle
GO:0048488 synaptic vesicle endocytosis
GO:0050918 positive chemotaxis
GO:0060088 auditory receptor cell stereocilium organization
GO:0060561 apoptotic process involved in morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0071896 protein localization to adherens junction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016323 basolateral plasma membrane
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035748 myelin sheath abaxonal region
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022568
View Gene Order
ENSBTAG00000008421
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_23
TSH pathway
REACTOME
REACT_172581
PCP/CE pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23513
UniGene Hs.436329 Hs.609801
RefSeq NM_015356 NM_182706
HUGO HGNC:30377
OMIM 607733
CCDS CCDS6411 CCDS6412
HPRD 06984
IMGT
EMBL
GenPept
RNA Seq Atlas 23513

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca