Homo sapiens Gene: SCRIB
Summary
InnateDB Gene IDBG-39063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCRIB
Gene Name scribbled homolog (Drosophila)
Synonyms CRIB1; SCRB1; SCRIB1; Vartul;
Species Homo sapiens
Ensembl Gene ENSG00000180900
Encoded Proteins
scribbled homolog (Drosophila)
scribbled homolog (Drosophila)
scribbled homolog (Drosophila)
scribbled homolog (Drosophila)
scribbled homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143790920-143815379
Strand Reverse strand
Band q24.3
Transcripts
ENST00000320476 ENSP00000322938
ENST00000356994 ENSP00000349486
ENST00000377533 ENSP00000366756
ENST00000531163
ENST00000525051
ENST00000526832 ENSP00000431519
ENST00000546337
ENST00000531942 ENSP00000433546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0001921 positive regulation of receptor recycling
GO:0002093 auditory receptor cell morphogenesis
GO:0008105 asymmetric protein localization
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0016080 synaptic vesicle targeting
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
GO:0021747 cochlear nucleus development
GO:0032863 activation of Rac GTPase activity
GO:0035089 establishment of apical/basal cell polarity
GO:0042060 wound healing
GO:0043065 positive regulation of apoptotic process
GO:0043615 astrocyte cell migration
GO:0045930 negative regulation of mitotic cell cycle
GO:0048488 synaptic vesicle endocytosis
GO:0050918 positive chemotaxis
GO:0060088 auditory receptor cell stereocilium organization
GO:0060561 apoptotic process involved in morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0071896 protein localization to adherens junction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016323 basolateral plasma membrane
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035748 myelin sheath abaxonal region
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TSH pathway
REACTOME
PCP/CE pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
Asymmetric localization of PCP proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436329 Hs.609801
RefSeq NM_015356 NM_182706
HUGO
OMIM
CCDS CCDS6411 CCDS6412
HPRD 06984
IMGT
EMBL
GenPept
RNA Seq Atlas