InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAT

Summary

InnateDB Protein

IDBP-39264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAT

Protein Name

catalase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000241052

InnateDB Gene

IDBG-39262 (CAT)

Protein Structure

UniProt Annotation

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. {ECO:0000269PubMed:7882369}.

Subcellular Localization

Peroxisome.

Disease Associations

Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0004096	catalase activity
GO:0005102	receptor binding
GO:0016209	antioxidant activity
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0050661	NADP binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001822	kidney development
GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006641	triglyceride metabolic process
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0009060	aerobic respiration
GO:0009650	UV protection
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027	hemoglobin metabolic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033197	response to vitamin E
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization
GO:0051781	positive regulation of cell division
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005764	lysosome
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR010582 Catalase immune-responsive domain
IPR011614 Catalase core domain
IPR018028 Catalase, mono-functional, haem-containing
IPR020835 Catalase-like domain

PFAM

PF06628
PF00199

PRINTS

PR00067

PIRSF

SMART

SM01060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt