Homo sapiens Gene: CAT
Summary
InnateDB Gene IDBG-39262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAT
Gene Name catalase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121691
Encoded Proteins
catalase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer\'s disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:34438925-34472062
Strand Forward strand
Band p13
Transcripts
ENST00000241052 ENSP00000241052
ENST00000528104
ENST00000530343
ENST00000525707
ENST00000534710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004046 aminoacylase activity
GO:0004096 catalase activity
GO:0005102 receptor binding
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0006144 purine nucleobase metabolic process
GO:0006195 purine nucleotide catabolic process
GO:0006641 triglyceride metabolic process
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0008203 cholesterol metabolic process
GO:0009060 aerobic respiration
GO:0009650 UV protection
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027 hemoglobin metabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033197 response to vitamin E
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051781 positive regulation of cell division
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055093 response to hyperoxia
GO:0055114 oxidation-reduction process
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005764 lysosome
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Purine metabolism pathway
Purine catabolism pathway
Detoxification of Reactive Oxygen Species pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Tryptophan metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
The igf-1 receptor and longevity [Biocarta view]
PID NCI
FoxO family signaling
Cross-References
SwissProt P04040
TrEMBL Q8TAK2
UniProt Splice Variant
Entrez Gene 847
UniGene Hs.502302
RefSeq NM_001752
HUGO HGNC:1516
OMIM 115500
CCDS CCDS7891
HPRD
IMGT
EMBL AK291585 AK315350 AL035079 AY028632 AY545477 BC027300 BC110398 BC112217 BC112219 CH471064 K02400 L13609 X04076 X04085 X04086 X04087 X04088 X04089 X04090 X04091 X04092 X04093 X04094 X04095 X04096
GenPept AAA16651 AAB59522 AAH27300 AAI10399 AAI12218 AAI12220 AAK29181 AAS37679 BAF84274 BAG37746 CAA27717 CAA27721 CAB45236 EAW68170 EAW68171
RNA Seq Atlas 847