InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP19

Summary

InnateDB Protein

IDBP-39278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP19

Protein Name

matrix metallopeptidase 19

Synonyms

MMP18; RASI-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000313437

InnateDB Gene

IDBG-39276 (MMP19)

Protein Structure

UniProt Annotation

Function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. {ECO:0000269PubMed:10809722, ECO:0000269PubMed:10922468}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.

Tissue Specificity

Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001542	ovulation from ovarian follicle
GO:0001554	luteolysis
GO:0006508	proteolysis
GO:0009725	response to hormone
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0051591	response to cAMP

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References