Version 5.4
Homo sapiens Gene: MMP19
Summary
InnateDB Gene IDBG-39276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP19
Gene Name matrix metallopeptidase 19
Synonyms MMP18; RASI-1
Species Homo sapiens
Ensembl Gene ENSG00000123342
Encoded Proteins
IDBP-39278
matrix metallopeptidase 19
IDBP-295453
matrix metallopeptidase 19
IDBP-586362
matrix metallopeptidase 19
IDBP-592706
matrix metallopeptidase 19
IDBP-595047
matrix metallopeptidase 19
IDBP-595992
matrix metallopeptidase 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55835433-55842966
Strand Reverse strand
Band q13.2
Transcripts
ENST00000322569 ENSP00000313437
ENST00000409200 ENSP00000386625
ENST00000548882 ENSP00000447363
ENST00000547685
ENST00000552872 ENSP00000446776
ENST00000548629 ENSP00000446979
ENST00000552763 ENSP00000449752
ENST00000547487
ENST00000547299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001542 ovulation from ovarian follicle
GO:0001554 luteolysis
GO:0006508 proteolysis
GO:0009725 response to hormone
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0051591 response to cAMP
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025355
View Gene Order
ENSBTAG00000009051
Not yet available
Pathways
NETPATH
REACTOME
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001272101 NM_002429
HUGO
OMIM
CCDS CCDS61146 CCDS8895
HPRD 03486
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca