InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF135

Summary

InnateDB Protein

IDBP-39374.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF135

Protein Name

ring finger protein 135

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323693

InnateDB Gene

IDBG-39370 (RNF135)

Protein Structure

UniProt Annotation

Function

Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269PubMed:19017631, ECO:0000269PubMed:19484123}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19484123}.

Disease Associations

Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192]: An autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. {ECO:0000269PubMed:17632510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. {ECO:0000269PubMed:19017631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response