InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF135

Summary

InnateDB Gene

IDBG-39370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF135

Gene Name

ring finger protein 135

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000181481

Encoded Proteins

IDBP-39372

ring finger protein 135

IDBP-39374

ring finger protein 135

IDBP-374686

ring finger protein 135

IDBP-762642

IDBP-584013

ring finger protein 135

IDBP-758661

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23950712

RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.

Entrez Gene

Summary

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:30968785-30999911

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000328381	ENSP00000328340
ENST00000324689	ENSP00000323693
ENST00000443677	ENSP00000411965
ENST00000434242	ENSP00000467799
ENST00000535306	ENSP00000440470
ENST00000580444	ENSP00000464549
ENST00000582674

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020707

View Gene Order

ENSBTAG00000017225

Not yet available

Pathways

NETPATH

REACTOME

REACT_24938

TRAF6 mediated IRF7 activation pathway

REACT_25271

Negative regulators of RIG-I/MDA5 signaling pathway

REACT_25026

TRAF3-dependent IRF activation pathway pathway

REACT_24969

TRAF6 mediated NF-kB activation pathway

REACT_25039

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8IUD6

TrEMBL

UniProt Splice Variant

Entrez Gene

84282

UniGene

Hs.29874

RefSeq

NM_001184992 NM_032322 NM_197939

HUGO

HGNC:21158

OMIM

611358

CCDS

CCDS54104 CCDS11262 CCDS11263

HPRD

11506

IMGT

EMBL

AB470605 AC138207 AJ496729 AK122646 AK312979 AY598332 BC005084 BC082262 BC126420 BC126422 CH471147

GenPept

AAH05084 AAI26421 AAI26423 AAT06743 BAG35816 BAG53638 BAG84604 CAD43140 EAW80286

RNA Seq Atlas

84282