Homo sapiens Gene: RNF135
Summary
InnateDB Gene IDBG-39370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF135
Gene Name ring finger protein 135
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000181481
Encoded Proteins
ring finger protein 135
ring finger protein 135
ring finger protein 135
ring finger protein 135
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RNF135 is essential for the association of DDX58 (RIG-I) and TRIM25, resulting in the activation of RIG-I signalling.
Entrez Gene
Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:30968785-30999911
Strand Forward strand
Band q11.2
Transcripts
ENST00000328381 ENSP00000328340
ENST00000324689 ENSP00000323693
ENST00000443677 ENSP00000411965
ENST00000434242 ENSP00000467799
ENST00000535306 ENSP00000440470
ENST00000580444 ENSP00000464549
ENST00000582674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0032480 negative regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Immune System pathway
TRAF3-dependent IRF activation pathway pathway
Negative regulators of RIG-I/MDA5 signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IUD6
TrEMBL
UniProt Splice Variant
Entrez Gene 84282
UniGene Hs.29874
RefSeq NM_197939 NM_032322 NM_001184992
HUGO HGNC:21158
OMIM 611358
CCDS CCDS11263 CCDS11262 CCDS54104
HPRD 11506
IMGT
EMBL AB470605 AC138207 AJ496729 AK122646 AK312979 AY598332 BC005084 BC082262 BC126420 BC126422 CH471147
GenPept AAH05084 AAI26421 AAI26423 AAT06743 BAG35816 BAG53638 BAG84604 CAD43140 EAW80286
RNA Seq Atlas 84282