InnateDB Protein
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IDBP-39436.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBXL3
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Protein Name
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F-box and leucine-rich repeat protein 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347834
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InnateDB Gene
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IDBG-39434 (FBXL3)
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Protein Structure
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Function |
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269PubMed:17463251, ECO:0000269PubMed:23452855}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10531035}. Cytoplasm {ECO:0000269PubMed:10531035}. Note=Predominantly nuclear.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:10531035}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0016567
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protein ubiquitination
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GO:0031146
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SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0031648
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protein destabilization
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GO:0042752
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regulation of circadian rhythm
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GO:0043153
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entrainment of circadian clock by photoperiod
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0048511
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rhythmic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKT7
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PhosphoSite |
PhosphoSite-Q9UKT7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26224
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UniGene |
Hs.713348
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RefSeq |
NP_036290
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HUGO |
HGNC:13599
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OMIM |
605653
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CCDS |
CCDS9457
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HPRD |
05737
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IMGT |
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EMBL |
AF126028
AF129532
AK314442
BC072448
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GenPept |
AAF04466
AAF37383
AAH72448
BAG37051
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