InnateDB Protein
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IDBP-39566.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD44
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Protein Name
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CD44 molecule (Indian blood group)
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Synonyms
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CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278386
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InnateDB Gene
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IDBG-39556 (CD44)
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Protein Structure
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Function |
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. {ECO:0000269PubMed:16541107}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
60
[view]
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Protein-Protein |
56
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0005975
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carbohydrate metabolic process
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GO:0007155
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cell adhesion
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GO:0007160
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cell-matrix adhesion
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GO:0007596
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blood coagulation
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GO:0016337
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single organismal cell-cell adhesion
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0022617
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extracellular matrix disassembly
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GO:0030198
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extracellular matrix organization
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GO:0030203
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glycosaminoglycan metabolic process
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GO:0030212
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hyaluronan metabolic process
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GO:0030214
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hyaluronan catabolic process
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GO:0033138
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positive regulation of peptidyl-serine phosphorylation
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GO:0034116
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positive regulation of heterotypic cell-cell adhesion
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GO:0043066
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negative regulation of apoptotic process
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043518
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negative regulation of DNA damage response, signal transduction by p53 class mediator
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GO:0044281
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small molecule metabolic process
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GO:0044344
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cellular response to fibroblast growth factor stimulus
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0050900
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leukocyte migration
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GO:0051216
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cartilage development
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GO:0060333
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interferon-gamma-mediated signaling pathway
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GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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GO:0070487
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monocyte aggregation
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GO:1900625
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positive regulation of monocyte aggregation
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GO:1902166
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negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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Cellular Component |
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PDB ID |
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InterPro |
IPR000538
Link
IPR016187
C-type lectin fold
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PFAM |
PF00193
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PRINTS |
PR01265
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PIRSF |
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SMART |
SM00445
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TIGRFAMs |
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Modification |
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SwissProt |
P16070
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PhosphoSite |
PhosphoSite-P16070
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TrEMBL |
C1PHC3
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UniProt Splice Variant |
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Entrez Gene |
960
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UniGene |
Hs.733491
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RefSeq |
NP_001001392
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HUGO |
HGNC:1681
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OMIM |
107269
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CCDS |
CCDS31458
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HPRD |
00115
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IMGT |
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EMBL |
AB469006
AF098641
AJ251595
AL133330
AL136989
AL356215
AL832642
AY101192
AY101193
BC004372
BC067348
CH471064
EF581837
FJ216964
L05407
L05408
L05409
L05410
L05411
L05412
L05414
L05415
L05416
L05417
L05418
L05419
L05420
L05421
L05422
L05423
L05424
M24915
M25078
M59040
M69215
S66400
S72928
U40373
X55150
X55938
X56794
X62739
X66733
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GenPept |
AAA35674
AAA36138
AAA51950
AAA82949
AAB13622
AAB13623
AAB13624
AAB13625
AAB13626
AAB13627
AAB13628
AAB27917
AAB27918
AAB27919
AAB30429
AAC70782
AAH04372
AAH67348
AAM50040
AAM50041
ABQ59315
ACI46596
BAH57528
CAA38951
CAA39404
CAA40133
CAA44602
CAA47271
CAB61878
CAC10347
CAD89965
EAW68147
EAW68148
EAW68149
EAW68151
EAW68152
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