InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PA2G4

Summary

InnateDB Protein

IDBP-39893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PA2G4

Protein Name

proliferation-associated 2G4, 38kDa

Synonyms

EBP1; HG4-1; p38-2G4;

Species

Homo sapiens

Ensembl Protein

ENSP00000302886

InnateDB Gene

IDBG-39891 (PA2G4)

Protein Structure

UniProt Annotation

Function

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG.

Disease Associations

Tissue Specificity

Expressed in several cell lines tested, including primary and transformed cell lines. {ECO:0000269PubMed:15064750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.

Experimentally validated
Total	98 [view]
Protein-Protein	88 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0006417	regulation of translation
GO:0007050	cell cycle arrest
GO:0008283	cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated