InnateDB Protein
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IDBP-39949.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPAA1
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Protein Name
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glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
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Synonyms
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GAA1; hGAA1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347206
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InnateDB Gene
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IDBG-39947 (GPAA1)
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Protein Structure
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Function |
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269PubMed:9468317}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:11483512}; Multi-pass membrane protein {ECO:0000269PubMed:11483512}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. {ECO:0000269PubMed:9468317}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007246
Gaa1-like, GPI transamidase component
IPR017063
Glycosylphosphatidylinositol:protein transamidase complex, GAA1 component
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PFAM |
PF04114
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PRINTS |
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PIRSF |
PIRSF036762
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43292
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PhosphoSite |
PhosphoSite-O43292
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TrEMBL |
E9PLG8
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UniProt Splice Variant |
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Entrez Gene |
8733
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UniGene |
Hs.627962
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RefSeq |
NP_003792
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HUGO |
HGNC:4446
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OMIM |
603048
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CCDS |
CCDS43776
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HPRD |
04334
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IMGT |
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EMBL |
AB002135
AB002137
AB006969
AB017267
AC109322
AL157437
BC003171
BC004129
BC006383
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GenPept |
AAH03171
AAH04129
AAH06383
BAA24035
BAA82587
BAA82588
BAA82590
CAB75660
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