InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPAA1

Summary

InnateDB Gene

IDBG-39947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPAA1

Gene Name

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

Synonyms

GAA1; hGAA1

Species

Homo sapiens

Ensembl Gene

ENSG00000197858

Encoded Proteins

IDBP-39949

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-39951

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-587608

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-590451

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-598695

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-588620

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-589529

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

IDBP-588735

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:144082590-144086216

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000355091	ENSP00000347206
ENST00000361036	ENSP00000354316
ENST00000529503	ENSP00000435024
ENST00000526341
ENST00000525087	ENSP00000434485
ENST00000532758
ENST00000530633	ENSP00000431233
ENST00000524418	ENSP00000434544
ENST00000528073	ENSP00000435119
ENST00000530258	ENSP00000435132
ENST00000527144
ENST00000525308
ENST00000526233
ENST00000527653
ENST00000529638
ENST00000531593
ENST00000530796
ENST00000534072

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003923	GPI-anchor transamidase activity
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0034235	GPI anchor binding

Biological Process

GO:0006461	protein complex assembly
GO:0006501	C-terminal protein lipidation
GO:0006621	protein retention in ER lumen
GO:0016255	attachment of GPI anchor to protein
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042765	GPI-anchor transamidase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022561

View Gene Order

ENSBTAG00000014610

Not yet available

Pathways

NETPATH

REACTOME

REACT_1830

Attachment of GPI anchor to uPAR pathway

REACT_1853

Post-translational modification: synthesis of GPI-anchored proteins pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00563

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PLG8 E9PPZ9

UniProt Splice Variant

Entrez Gene

8733

UniGene

Hs.627962

RefSeq

NM_003801

HUGO

HGNC:4446

OMIM

603048

CCDS

CCDS43776

HPRD

04334

IMGT

EMBL

AC109322

GenPept

RNA Seq Atlas

8733