Homo sapiens Gene: GPAA1
Summary
InnateDB Gene IDBG-39947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPAA1
Gene Name glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
Synonyms GAA1; hGAA1;
Species Homo sapiens
Ensembl Gene ENSG00000197858
Encoded Proteins
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144082590-144086216
Strand Forward strand
Band q24.3
Transcripts
ENST00000355091 ENSP00000347206
ENST00000361036 ENSP00000354316
ENST00000529503 ENSP00000435024
ENST00000526341
ENST00000525087 ENSP00000434485
ENST00000532758
ENST00000530633 ENSP00000431233
ENST00000524418 ENSP00000434544
ENST00000528073 ENSP00000435119
ENST00000530258 ENSP00000435132
ENST00000527144
ENST00000525308
ENST00000526233
ENST00000527653
ENST00000529638
ENST00000531593
ENST00000530796
ENST00000534072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006461 protein complex assembly
GO:0006501 C-terminal protein lipidation
GO:0006621 protein retention in ER lumen
GO:0016255 attachment of GPI anchor to protein
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Metabolism of proteins pathway
Attachment of GPI anchor to uPAR pathway
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.627962
RefSeq NM_003801
HUGO
OMIM
CCDS CCDS43776
HPRD 04334
IMGT
EMBL
GenPept
RNA Seq Atlas