InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPAA1

Summary

InnateDB Protein

IDBP-39951.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPAA1

Protein Name

glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

Synonyms

GAA1; hGAA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354316

InnateDB Gene

IDBG-39947 (GPAA1)

Protein Structure

UniProt Annotation

Function

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269PubMed:9468317}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:11483512}; Multi-pass membrane protein {ECO:0000269PubMed:11483512}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. {ECO:0000269PubMed:9468317}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003923	GPI-anchor transamidase activity
GO:0005515	protein binding
GO:0015631	tubulin binding
GO:0034235	GPI anchor binding

Biological Process

GO:0006461	protein complex assembly
GO:0006501	C-terminal protein lipidation
GO:0006621	protein retention in ER lumen
GO:0016255	attachment of GPI anchor to protein
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process