InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga3

Summary

InnateDB Protein

IDBP-400078.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga3

Protein Name

integrin alpha 3

Synonyms

AA407068; CD49C; GAPB3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113556

InnateDB Gene

IDBG-209447 (Itga3)

Protein Structure

UniProt Annotation

Function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in heart and brain. Only isoform 1 is detected in lung. {ECO:0000269PubMed:1946438}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019904	protein domain specific binding
GO:0043236	laminin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0007613	memory
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010976	positive regulation of neuron projection development
GO:0031345	negative regulation of cell projection organization
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016323	basolateral plasma membrane
GO:0030426	growth cone
GO:0034667	integrin alpha3-beta1 complex
GO:0043235	receptor complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm