Version 5.4
Homo sapiens Protein: SCEL
Summary
InnateDB Protein IDBP-40008.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCEL
Protein Name sciellin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366454
InnateDB Gene IDBG-40000 (SCEL)
Protein Structure
UniProt Annotation
Function May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Subcellular Localization Cytoplasm. Membrane. Note=May become cross- linked to membrane proteins by transglutaminase.
Disease Associations
Tissue Specificity Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0008544 epidermis development
GO:0009790 embryo development
GO:0030216 keratinocyte differentiation
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95171
PhosphoSite PhosphoSite-O95171
TrEMBL
UniProt Splice Variant
Entrez Gene 8796
UniGene Hs.591224
RefSeq NP_003834
HUGO HGNC:10573
OMIM 604112
CCDS CCDS9458
HPRD 09161
IMGT
EMBL AF045941 AK222720 AK301659 AL137140 BC047536 CH471093
GenPept AAC78461 AAH47536 BAD96440 BAH13533 CAH70475 CAH70476 EAW80568 EAW80569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca