Version 5.4
Mus musculus Protein: Sh2b3
Summary
InnateDB Protein IDBP-400291.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2b3
Protein Name SH2B adaptor protein 3
Synonyms AI429800; Lnk;
Species Mus musculus
Ensembl Protein ENSMUSP00000113926
InnateDB Gene IDBG-197739 (Sh2b3)
Protein Structure
UniProt Annotation
Function Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042301 phosphate ion binding
Biological Process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0035162 embryonic hemopoiesis
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID MGI:893598
InterPro IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015012 Phenylalanine zipper
PFAM PF00017
PF14633
PF00169
PF08916
PRINTS PR00401
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09039
PhosphoSite PhosphoSite-O09039
TrEMBL D3Z0T9
UniProt Splice Variant
Entrez Gene 16923
UniGene Mm.65493
RefSeq
MGI ID
MGI Symbol Sh2b3
OMIM
CCDS CCDS19641
HPRD
IMGT
EMBL AC113302 BC006759 U89992 U89993
GenPept AAB58580 AAB58581 AAH06759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca