Version 5.4
Mus musculus Gene: Sh2b3
Summary
InnateDB Gene IDBG-197739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2b3
Gene Name SH2B adaptor protein 3
Synonyms AI429800; Lnk
Species Mus musculus
Ensembl Gene ENSMUSG00000042594
Encoded Proteins
IDBP-197741
SH2B adaptor protein 3
IDBP-197743
SH2B adaptor protein 3
IDBP-400291
SH2B adaptor protein 3
IDBP-400290
SH2B adaptor protein 3
IDBP-537771
SH2B adaptor protein 3
IDBP-539019
SH2B adaptor protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111252:
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010]
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:121815488-121836859
Strand Reverse strand
Band F
Transcripts
ENSMUST00000086310 ENSMUSP00000083490
ENSMUST00000040308 ENSMUSP00000041611
ENSMUST00000122426 ENSMUSP00000113926
ENSMUST00000118580 ENSMUSP00000113808
ENSMUST00000136960 ENSMUSP00000119086
ENSMUST00000137682 ENSMUSP00000118523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042301 phosphate ion binding
Biological Process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0035162 embryonic hemopoiesis
GO:0035556 intracellular signal transduction
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111252
View Gene Order
ENSBTAG00000009101
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
REACT_604
Hemostasis pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
epopathway
EPO signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL D3Z0T9 D6RCY9
UniProt Splice Variant
Entrez Gene 16923
UniGene Mm.437534 Mm.470237 Mm.65493
RefSeq NM_008507 XM_006530169 XM_006530170 XM_006530171 XM_006530172 XM_006530173
OMIM
CCDS CCDS19641
HPRD
IMGT
MGI ID MGI:893598
MGI Symbol Sh2b3
EMBL AC113302
GenPept
RNA Seq Atlas 16923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca