Mus musculus Protein: Cth
Summary
InnateDB Protein IDBP-400313.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cth
Protein Name cystathionase (cystathionine gamma-lyase)
Synonyms 0610010I13Rik; AI314617; BC019483; CSE; Cys3;
Species Mus musculus
Ensembl Protein ENSMUSP00000113672
InnateDB Gene IDBG-201114 (Cth)
Protein Structure
UniProt Annotation
Function Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269PubMed:18948540, ECO:0000269PubMed:19903941, ECO:0000269PubMed:22244329}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in liver and kidney, and at lower levels in small intestine (at protein level). Highly expressed in liver and kidney. detected at lower levels in stomach, small intestine and adipose tissue. {ECO:0000269PubMed:15038791}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004123 cystathionine gamma-lyase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0030170 pyridoxal phosphate binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344 cysteine biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524 protein sulfhydration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051289 protein homotetramerization
GO:0070814 hydrogen sulfide biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1339968
InterPro IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00266
PF01053
PF01041
PF00155
PRINTS
PIRSF PIRSF001434
PIRSF000390
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCN5
PhosphoSite PhosphoSite-Q8VCN5
TrEMBL
UniProt Splice Variant
Entrez Gene 107869
UniGene Mm.28301
RefSeq NP_666065
MGI ID
MGI Symbol Cth
OMIM
CCDS CCDS51101
HPRD
IMGT
EMBL AY083352 AY262829 BC019483 CH466532
GenPept AAH19483 AAL99218 AAP86975 EDL11858