InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cth

Summary

InnateDB Protein

IDBP-400313.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cth

Protein Name

cystathionase (cystathionine gamma-lyase)

Synonyms

0610010I13Rik; AI314617; BC019483; CSE; Cys3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113672

InnateDB Gene

IDBG-201114 (Cth)

Protein Structure

UniProt Annotation

Function

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269PubMed:18948540, ECO:0000269PubMed:19903941, ECO:0000269PubMed:22244329}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in liver and kidney, and at lower levels in small intestine (at protein level). Highly expressed in liver and kidney. detected at lower levels in stomach, small intestine and adipose tissue. {ECO:0000269PubMed:15038791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004123	cystathionine gamma-lyase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030170	pyridoxal phosphate binding
GO:0044540	L-cystine L-cysteine-lyase (deaminating)
GO:0080146	L-cysteine desulfhydrase activity

Biological Process

GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344	cysteine biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524	protein sulfhydration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051289	protein homotetramerization
GO:0070814	hydrogen sulfide biosynthetic process
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1339968

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01053
PF01041
PF00155

PRINTS

PIRSF

PIRSF001434
PIRSF000390

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VCN5