InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cth

Summary

InnateDB Gene

IDBG-201114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cth

Gene Name

cystathionase (cystathionine gamma-lyase)

Synonyms

0610010I13Rik; AI314617; BC019483; CSE; Cys3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028179

Encoded Proteins

IDBP-400313

cystathionase (cystathionine gamma-lyase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116761:
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:157894248-157925077

Strand

Reverse strand

Band

Transcripts

ENSMUST00000118539	ENSMUSP00000113672
ENSMUST00000129805
ENSMUST00000125028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004123	cystathionine gamma-lyase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030170	pyridoxal phosphate binding
GO:0044540	L-cystine L-cysteine-lyase (deaminating)
GO:0080146	L-cysteine desulfhydrase activity

Biological Process

GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0019344	cysteine biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524	protein sulfhydration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051289	protein homotetramerization
GO:0070814	hydrogen sulfide biosynthetic process
GO:2001234	negative regulation of apoptotic signaling pathway