InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Disc1

Summary

InnateDB Protein

IDBP-400332.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Disc1

Protein Name

disrupted in schizophrenia 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112410

InnateDB Gene

IDBG-200561 (Disc1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19303846, ECO:0000269PubMed:19502360, ECO:0000269PubMed:19778506}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19502360}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0002052	positive regulation of neuroblast proliferation
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021846	cell proliferation in forebrain
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031929	TOR signaling
GO:0034613	cellular protein localization
GO:0051560	mitochondrial calcium ion homeostasis
GO:0060070	canonical Wnt signaling pathway
GO:0090128	regulation of synapse maturation
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005874	microtubule
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0036064	ciliary basal body
GO:0045211	postsynaptic membrane