Mus musculus Gene: Disc1
InnateDB Gene IDBG-200561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Disc1
Gene Name disrupted in schizophrenia 1
Species Mus musculus
Ensembl Gene ENSMUSG00000043051
Encoded Proteins
disrupted in schizophrenia 1
disrupted in schizophrenia 1
disrupted in schizophrenia 1
disrupted in schizophrenia 1
disrupted in schizophrenia 1
disrupted in schizophrenia 1
disrupted in schizophrenia 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162946:
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:125054195-125261858
Strand Forward strand
Band E2
ENSMUST00000074562 ENSMUSP00000074147
ENSMUST00000075730 ENSMUSP00000075145
ENSMUST00000098311 ENSMUSP00000095914
ENSMUST00000118942 ENSMUSP00000112410
ENSMUST00000117658 ENSMUSP00000112757
ENSMUST00000122389 ENSMUSP00000112593
ENSMUST00000121953 ENSMUSP00000112929
ENSMUST00000115885 ENSMUSP00000111552
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 115 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0008104 protein localization
GO:0010975 regulation of neuron projection development
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021846 cell proliferation in forebrain
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031929 TOR signaling
GO:0034613 cellular protein localization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0060070 canonical Wnt signaling pathway
GO:0090128 regulation of synapse maturation
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0036064 ciliary basal body
GO:0045211 postsynaptic membrane
Homo sapiens
Gene ID
Gene Order
SwissProt Q811T9
UniProt Splice Variant
Entrez Gene 244667
UniGene Mm.233504
RefSeq NM_174853 NM_174854 XM_006531021 XM_006531022
CCDS CCDS40517 CCDS52707
MGI ID MGI:2447658
MGI Symbol Disc1
EMBL AF513723 AF513724 AJ506179 AJ506180 AY177673 AY320287
GenPept AAN77091 AAN77092 AAO19641 AAP83943 CAD44629 CAD44630
RNA Seq Atlas 244667