InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Disc1

Summary

InnateDB Gene

IDBG-200561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Disc1

Gene Name

disrupted in schizophrenia 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043051

Encoded Proteins

IDBP-200563

disrupted in schizophrenia 1

IDBP-200565

disrupted in schizophrenia 1

IDBP-200567

disrupted in schizophrenia 1

IDBP-400332

disrupted in schizophrenia 1

IDBP-400326

disrupted in schizophrenia 1

IDBP-400327

disrupted in schizophrenia 1

IDBP-400325

disrupted in schizophrenia 1

IDBP-718067

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162946:
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:125054195-125261858

Strand

Forward strand

Band

Transcripts

ENSMUST00000074562	ENSMUSP00000074147
ENSMUST00000075730	ENSMUSP00000075145
ENSMUST00000098311	ENSMUSP00000095914
ENSMUST00000118942	ENSMUSP00000112410
ENSMUST00000117658	ENSMUSP00000112757
ENSMUST00000122389	ENSMUSP00000112593
ENSMUST00000121953	ENSMUSP00000112929
ENSMUST00000126111
ENSMUST00000115885	ENSMUSP00000111552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0002052	positive regulation of neuroblast proliferation
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021846	cell proliferation in forebrain
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031929	TOR signaling
GO:0034613	cellular protein localization
GO:0051560	mitochondrial calcium ion homeostasis
GO:0060070	canonical Wnt signaling pathway
GO:0090128	regulation of synapse maturation
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005874	microtubule
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0036064	ciliary basal body
GO:0045211	postsynaptic membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000162946

View Gene Order

Cross-References

SwissProt

Q811T9

TrEMBL

UniProt Splice Variant

Entrez Gene

244667

UniGene

Mm.233504

RefSeq

NM_174853 NM_174854 XM_006531021 XM_006531022

OMIM

CCDS

CCDS40517 CCDS52707

HPRD

IMGT

MGI ID

MGI:2447658

MGI Symbol

Disc1

EMBL

AF513723 AF513724 AJ506179 AJ506180 AY177673 AY320287

GenPept

AAN77091 AAN77092 AAO19641 AAP83943 CAD44629 CAD44630

RNA Seq Atlas

244667