Version 5.4
Mus musculus Protein: Stat6
Summary
InnateDB Protein IDBP-400352.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stat6
Protein Name signal transducer and activator of transcription 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112722
InnateDB Gene IDBG-195602 (Stat6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 18 [view]
Protein-DNA 17 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002296 T-helper 1 cell lineage commitment
GO:0002829 negative regulation of type 2 immune response
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0033598 mammary gland epithelial cell proliferation
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0060443 mammary gland morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:103034
InterPro IPR013799 STAT transcription factor, protein interaction
PFAM PF02865
PRINTS
PIRSF
SMART SM00964
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YU28
UniProt Splice Variant
Entrez Gene 20852
UniGene Mm.121721
RefSeq
MGI ID
MGI Symbol Stat6
OMIM
CCDS
HPRD
IMGT
EMBL AC160970
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca