Version 5.4
Mus musculus Protein: Hsd17b11
Summary
InnateDB Protein IDBP-400485.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd17b11
Protein Name hydroxysteroid (17-beta) dehydrogenase 11
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113455
InnateDB Gene IDBG-185193 (Hsd17b11)
Protein Structure
UniProt Annotation
Function Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.
Subcellular Localization Secreted {ECO:0000305}. Cytoplasm. Note=According to PubMed:12697717 it is cytoplasmic. However, the relevance of such result remains unclear.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006710 androgen catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005811 lipid particle
Protein Structure and Domains
PDB ID MGI:2149821
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EQ06
PhosphoSite PhosphoSite-Q9EQ06
TrEMBL
UniProt Splice Variant
Entrez Gene 114664
UniGene Mm.490893
RefSeq
MGI ID
MGI Symbol Hsd17b11
OMIM
CCDS
HPRD
IMGT
EMBL AF304306 AK049355 AK154803 AK155174 AK155202 AK155327 AK158327 AK170939 AY053570 BC038340
GenPept AAG41413 AAH38340 AAL14859 BAC33704 BAE32840 BAE33094 BAE33115 BAE33194 BAE34459 BAE42129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca