InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5f1

Summary

InnateDB Protein

IDBP-400619.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5f1

Protein Name

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1

Synonyms

C76477;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113022

InnateDB Gene

IDBG-183928 (Atp5f1)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0021762	substantia nigra development

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome