InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif2a

Summary

InnateDB Protein

IDBP-400650.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif2a

Protein Name

kinesin family member 2A

Synonyms

C530030B14Rik; Kif2; Kns2; M-kinesin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112715

InnateDB Gene

IDBG-181060 (Kif2a)

Protein Structure

UniProt Annotation

Function

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Lysosome {ECO:0000269PubMed:9774330}. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1 (By similarity). Associated with lysosomes in NIH3T3 cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). Isoform 1 expressed in neuronal cells. Isoform 2 expressed in astrocytes and fibroblasts. {ECO:0000269PubMed:9774330}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0030154	cell differentiation