InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt6

Summary

InnateDB Protein

IDBP-400694.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt6

Protein Name

synaptotagmin VI

Synonyms

3110037A08Rik; AW048930; sytVI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112997

InnateDB Gene

IDBG-181512 (Syt6)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm. {ECO:0000250, ECO:0000269PubMed:15774481}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269PubMed:10531344}; Single- pass membrane protein {ECO:0000269PubMed:10531344}.Isoform 1: Membrane; Single-pass membrane protein. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment.Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in the olfactory bulb. Isoform 2 is expressed in the brain (at protein level).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007340

acrosome reaction

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0019898	extrinsic component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0097038	perinuclear endoplasmic reticulum