InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sufu

Summary

InnateDB Protein

IDBP-400941.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sufu

Protein Name

suppressor of fused homolog (Drosophila)

Synonyms

Su(fu);

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113073

InnateDB Gene

IDBG-173162 (Sufu)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0001947	heart looping
GO:0007368	determination of left/right symmetry
GO:0021513	spinal cord dorsal/ventral patterning
GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043588	skin development
GO:0045879	negative regulation of smoothened signaling pathway
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005929	cilium
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

MGI:1345643

InterPro

IPR020941 Suppressor of fused-like domain
IPR024314 Suppressor of fused C-terminal

PFAM

PF05076
PF12470

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z7B6

UniProt Splice Variant

Entrez Gene

24069

UniGene

Mm.41210

RefSeq

MGI ID

MGI Symbol

Sufu

OMIM

CCDS

HPRD

IMGT

EMBL

AC114539 AC156982

GenPept