InnateDB Protein
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IDBP-400942.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sufu
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Protein Name
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suppressor of fused homolog (Drosophila)
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Synonyms
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Su(fu);
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112653
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InnateDB Gene
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IDBG-173162 (Sufu)
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Protein Structure
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Function |
Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation. {ECO:0000269PubMed:10531011, ECO:0000269PubMed:11477086, ECO:0000269PubMed:11960000, ECO:0000269PubMed:20360384, ECO:0000269PubMed:23034632}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed in adult and fetal tissues. {ECO:0000269PubMed:10531011, ECO:0000269PubMed:11557033}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
46
[view]
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Protein-Protein |
40
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
5
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001843
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neural tube closure
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GO:0001947
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heart looping
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GO:0007368
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determination of left/right symmetry
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GO:0021513
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spinal cord dorsal/ventral patterning
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GO:0021775
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smoothened signaling pathway involved in ventral spinal cord interneuron specification
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GO:0021776
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smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
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GO:0042994
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cytoplasmic sequestering of transcription factor
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GO:0043588
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skin development
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GO:0045879
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negative regulation of smoothened signaling pathway
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GO:1901621
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negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
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GO:2000059
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negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
MGI:1345643
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InterPro |
IPR020941
Suppressor of fused-like domain
IPR024314
Suppressor of fused C-terminal
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PFAM |
PF05076
PF12470
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0P7
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PhosphoSite |
PhosphoSite-Q9Z0P7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
24069
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UniGene |
Mm.41210
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RefSeq |
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MGI ID |
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MGI Symbol |
Sufu
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF134893
AJ131692
AJ308625
AJ308626
AJ308627
AJ308628
AJ308629
AJ308630
AJ308631
AJ308632
AJ308633
AJ308634
AJ308635
AK015885
AK047603
BC048168
BC056997
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GenPept |
AAF61412
AAH48168
AAH56997
BAB30017
BAC33095
CAB38081
CAC34257
CAC34258
CAC34271
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