InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab27b

Summary

InnateDB Protein

IDBP-401272.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab27b

Protein Name

RAB27b, member RAS oncogene family

Synonyms

2310021G14Rik; B130064M09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112807

InnateDB Gene

IDBG-156998 (Rab27b)

Protein Structure

UniProt Annotation

Function

May be involved in targeting uroplakins to urothelial apical membranes. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed abundantly in the stomach and is predominantly localized at the apical region of gastric-surface mucus cells. Also expressed in the brain and spleen. {ECO:0000269PubMed:16716193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0045921	positive regulation of exocytosis
GO:0071985	multivesicular body sorting pathway

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0032585	multivesicular body membrane
GO:0042589	zymogen granule membrane

Protein Structure and Domains

PDB ID

MGI:1931295

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt