Version 5.4
| Mus musculus Protein: Hecw2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-401340.4 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Hecw2 | ||||||||
| Protein Name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000113283 | ||||||||
| InnateDB Gene | IDBG-154418 (Hecw2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2685817 | ||||||||
| InterPro |
IPR000008
C2 domain IPR000569 HECT IPR001202 WW domain |
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| PFAM |
PF00168
PF00632 PF00397 |
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| PRINTS |
PR00360
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| PIRSF | |||||||||
| SMART |
SM00239
SM00119 SM00456 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6I6G8 | ||||||||
| PhosphoSite | PhosphoSite-Q6I6G8 | ||||||||
| TrEMBL | Q8BQD5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 329152 | ||||||||
| UniGene | Mm.447527 | ||||||||
| RefSeq | XP_006496129 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Hecw2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS14956 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB182244 AK042922 AK050978 AK129325 BC107219 BC134353 CH466548 | ||||||||
| GenPept | AAI07220 AAI34354 BAC31406 BAC34482 BAC98135 BAD23960 EDL00005 | ||||||||