InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Numb

Summary

InnateDB Protein

IDBP-401347.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Numb

Protein Name

numb gene homolog (Drosophila)

Synonyms

Nb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113591

InnateDB Gene

IDBG-155803 (Numb)

Protein Structure

UniProt Annotation

Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. {ECO:0000269PubMed:10841580, ECO:0000269PubMed:12410312, ECO:0000269PubMed:15273690, ECO:0000269PubMed:17174898}.

Subcellular Localization

Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Expressed in subventricular zone (SVZ) neuroprogenitors and ependymal cells. {ECO:0000269PubMed:17174898}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0030862	positive regulation of polarized epithelial cell differentiation
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0045746	negative regulation of Notch signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016323	basolateral plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0045177	apical part of cell