InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Numb

Summary

InnateDB Gene

IDBG-155803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Numb

Gene Name

numb gene homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021224

Encoded Proteins

IDBP-155805

numb gene homolog (Drosophila)

IDBP-155807

numb gene homolog (Drosophila)

IDBP-260569

numb gene homolog (Drosophila)

IDBP-401347

numb gene homolog (Drosophila)

IDBP-536741

numb gene homolog (Drosophila)

IDBP-531546

numb gene homolog (Drosophila)

IDBP-539129

numb gene homolog (Drosophila)

IDBP-539752

numb gene homolog (Drosophila)

IDBP-535869

numb gene homolog (Drosophila)

IDBP-538646

numb gene homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24092752

Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.

Entrez Gene

Summary

This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:83794034-83921934

Strand

Reverse strand

Band

Transcripts

ENSMUST00000085215	ENSMUSP00000082311
ENSMUST00000021647	ENSMUSP00000021647
ENSMUST00000110298	ENSMUSP00000105927
ENSMUST00000117217	ENSMUSP00000113591
ENSMUST00000129335	ENSMUSP00000119303
ENSMUST00000154043	ENSMUSP00000117899
ENSMUST00000155112	ENSMUSP00000116863
ENSMUST00000135962	ENSMUSP00000122977
ENSMUST00000136848	ENSMUSP00000122597
ENSMUST00000126943	ENSMUSP00000122960
ENSMUST00000125089

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0030862	positive regulation of polarized epithelial cell differentiation
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0045087	innate immune response (InnateDB)
GO:0045746	negative regulation of Notch signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016323	basolateral plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0045177	apical part of cell