Version 5.4
Mus musculus Protein: Hmga1
Summary
InnateDB Protein IDBP-401355.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmga1
Protein Name high mobility group AT-hook 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113015
InnateDB Gene IDBG-156806 (Hmga1)
Protein Structure
UniProt Annotation
Function HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0090402 oncogene-induced cell senescence
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0035985 senescence-associated heterochromatin focus
Protein Structure and Domains
PDB ID MGI:96160
InterPro IPR000116 High mobility group, HMG-I/HMG-Y
IPR017956 AT hook, DNA-binding motif
IPR020478 AT hook-like
PFAM PF02178
PRINTS PR00930
PR00929
PIRSF
SMART SM00384
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17095
PhosphoSite PhosphoSite-P17095
TrEMBL Q566K0
UniProt Splice Variant
Entrez Gene 15361
UniGene Mm.487393
RefSeq
MGI ID
MGI Symbol Hmga1
OMIM
CCDS CCDS28564
HPRD
IMGT
EMBL AF285780 AK010617 AK154957 AK169783 AK171334 BC013455 BC093496 J04179
GenPept AAA37820 AAH13455 AAH93496 AAK66158 AAK66159 BAB27065 BAE32952 BAE41363 BAE42398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca