Version 5.4
Mus musculus Gene: Hmga1
Summary
InnateDB Gene IDBG-156806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmga1
Gene Name high mobility group AT-hook 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046711
Encoded Proteins
IDBP-250815
high mobility group AT-hook 1
IDBP-401354
high mobility group AT-hook 1
IDBP-401353
high mobility group AT-hook 1
IDBP-401355
high mobility group AT-hook 1
IDBP-401352
high mobility group AT-hook 1
IDBP-401351
high mobility group AT-hook 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27556620-27563674
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000114888 ENSMUSP00000110538
ENSMUST00000117600 ENSMUSP00000113068
ENSMUST00000119486 ENSMUSP00000113916
ENSMUST00000118599 ENSMUSP00000113015
ENSMUST00000118570 ENSMUSP00000114101
ENSMUST00000117254 ENSMUSP00000113011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0090402 oncogene-induced cell senescence
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0035985 senescence-associated heterochromatin focus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000137309
View Gene Order
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188820
Cellular Senescence pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9406
APOBEC3G mediated resistance to HIV-1 infection pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_9058
2-LTR circle formation pathway
REACT_6866
Autointegration results in viral DNA circles pathway
REACT_6918
Integration of provirus pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_120956
Cellular responses to stress pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_8990
Integration of viral DNA into host genomic DNA pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P17095
TrEMBL Q3TE85 Q566K0
UniProt Splice Variant
Entrez Gene 15361
UniGene Mm.310750 Mm.426212 Mm.4438 Mm.487393
RefSeq NM_016660 NM_001025427 NM_001039356 NM_001166535 NM_001166536 NM_001166537 NM_001166539 NM_001166540 NM_001166541 NM_001166542 NM_001166543 NM_001166544 NM_001166545 NM_001166546
OMIM
CCDS CCDS28564 CCDS50044
HPRD
IMGT
MGI ID MGI:96160
MGI Symbol Hmga1
EMBL AF285780 AK010617 AK154957 AK169783 AK171334 BC013455 BC093496 J04179
GenPept AAA37820 AAH13455 AAH93496 AAK66158 AAK66159 BAB27065 BAE32952 BAE41363 BAE42398
RNA Seq Atlas 111241 15361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca