InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Otx2

Summary

InnateDB Protein

IDBP-401360.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Otx2

Protein Name

orthodenticle homolog 2 (Drosophila)

Synonyms

E130306E05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112532

InnateDB Gene

IDBG-155303 (Otx2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0007492	endoderm development
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0022037	metencephalon development
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0032525	somite rostral/caudal axis specification
GO:0042472	inner ear morphogenesis
GO:0042706	eye photoreceptor cell fate commitment
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048663	neuron fate commitment
GO:0048664	neuron fate determination
GO:0048852	diencephalon morphogenesis
GO:0048856	anatomical structure development
GO:0090009	primitive streak formation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030426	growth cone
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:97451

InterPro

IPR001356 Homeobox domain
IPR003022 Transcription factor Otx2
IPR003025 Transcription factor Otx
IPR009057 Homeodomain-like
IPR013851 Transcription factor Otx, C-terminal

PFAM

PF00046
PF03529

PRINTS

PR01257
PR01255

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt