InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC27A6

Summary

InnateDB Protein

IDBP-40138.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A6

Protein Name

solute carrier family 27 (fatty acid transporter), member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262462

InnateDB Gene

IDBG-40136 (SLC27A6)

Protein Structure

UniProt Annotation

Function

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. {ECO:0000269PubMed:12556534}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. {ECO:0000269PubMed:12556534}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0031957	very long-chain fatty acid-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0008152	metabolic process
GO:0015909	long-chain fatty acid transport
GO:0055085	transmembrane transport