InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdia2

Summary

InnateDB Protein

IDBP-401405.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdia2

Protein Name

protein disulfide isomerase associated 2

Synonyms

1810041F13Rik; AI661267; Pdip; Pdipl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114080

InnateDB Gene

IDBG-154856 (Pdia2)

Protein Structure

UniProt Annotation

Function

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity). {ECO:0000250UniProtKB:Q13087}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250UniProtKB:Q13087, ECO:0000255PROSITE- ProRule:PRU10138}.

Disease Associations

Tissue Specificity

Highly expressed in pancreas. {ECO:0000269PubMed:9115635}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005496	steroid binding
GO:0016853	isomerase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0006457	protein folding
GO:0019511	peptidyl-proline hydroxylation
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:1916441

InterPro

IPR005792 Protein disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain

PFAM

PF13098
PF13192
PF13462
PF13905
PF00085

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

D3Z6P0

PhosphoSite

PhosphoSite-D3Z6P0

TrEMBL

UniProt Splice Variant

Entrez Gene

69191

UniGene

Mm.32631

RefSeq

MGI ID

MGI Symbol

Pdia2

OMIM

CCDS

HPRD

IMGT

EMBL

AC126438 BC116671

GenPept

AAI16672