Version 5.4
Mus musculus Protein: Adrb3
Summary
InnateDB Protein IDBP-401471.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adrb3
Protein Name adrenergic receptor, beta 3
Synonyms Adrb-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000113732
InnateDB Gene IDBG-145892 (Adrb3)
Protein Structure
UniProt Annotation
Function Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity White and brown adipose tissues, and digestive tract. Isoform B highest in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004939 beta-adrenergic receptor activity
GO:0015052 beta3-adrenergic receptor activity
GO:0031699 beta-3 adrenergic receptor binding
GO:0042803 protein homodimerization activity
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
Biological Process
GO:0002024 diet induced thermogenesis
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007568 aging
GO:0009409 response to cold
GO:0031649 heat generation
GO:0040015 negative regulation of multicellular organism growth
GO:0042755 eating behavior
GO:0043410 positive regulation of MAPK cascade
GO:0046677 response to antibiotic
GO:0050873 brown fat cell differentiation
GO:0071875 adrenergic receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:87939
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000681 Beta 3 adrenoceptor
IPR002232 5-Hydroxytryptamine 6 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00563
PR01102
PR01103
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P25962
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11556
UniGene Mm.278475
RefSeq
MGI ID
MGI Symbol Adrb3
OMIM
CCDS
HPRD
IMGT
EMBL AF193027 BC132000 S53290 X60438 X72862
GenPept AAB24836 AAF05768 AAI32001 CAA42966 CAA51384

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca