Mus musculus Protein: S1pr5 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-401605.4 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | S1pr5 | ||||||
Protein Name | sphingosine-1-phosphate receptor 5 | ||||||
Synonyms | Edg8; lpB4; S1P5; | ||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000113843 | ||||||
InnateDB Gene | IDBG-139595 (S1pr5) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. {ECO:0000250, ECO:0000269PubMed:15703400}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes. {ECO:0000269PubMed:11705398, ECO:0000269PubMed:15703400}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2150641 | ||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR002230 Cannabinoid receptor family IPR004061 Sphingosine 1-phosphate receptor IPR005386 EDG-8 sphingosine 1-phosphate receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00237
PR00362 PR01523 PR01561 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q91X56 | ||||||
PhosphoSite | PhosphoSite-Q91X56 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 94226 | ||||||
UniGene | Mm.190619 | ||||||
RefSeq | NP_444420 | ||||||
MGI ID | |||||||
MGI Symbol | S1pr5 | ||||||
OMIM | |||||||
CCDS | CCDS22898 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AF327535 AK081126 BC012232 | ||||||
GenPept | AAH12232 AAK15485 BAC38142 | ||||||