Homo sapiens Protein: EDNRA
InnateDB Protein IDBP-40280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDNRA
Protein Name endothelin receptor type A
Synonyms ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR;
Species Homo sapiens
Ensembl Protein ENSP00000315011
InnateDB Gene IDBG-40278 (EDNRA)
Protein Structure
UniProt Annotation
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269PubMed:8611157, ECO:0000269PubMed:9284755}.
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004930 G-protein coupled receptor activity
GO:0004962 endothelin receptor activity
GO:0005515 protein binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001821 histamine secretion
GO:0001934 positive regulation of protein phosphorylation
GO:0003094 glomerular filtration
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0007507 heart development
GO:0007568 aging
GO:0007585 respiratory gaseous exchange
GO:0008152 metabolic process
GO:0008217 regulation of blood pressure
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0014032 neural crest cell development
GO:0014070 response to organic cyclic compound
GO:0014824 artery smooth muscle contraction
GO:0015758 glucose transport
GO:0019233 sensory perception of pain
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0042310 vasoconstriction
GO:0042482 positive regulation of odontogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043084 penile erection
GO:0043278 response to morphine
GO:0048144 fibroblast proliferation
GO:0048484 enteric nervous system development
GO:0048659 smooth muscle cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928 positive regulation of calcium ion transport
GO:0060137 maternal process involved in parturition
GO:0060322 head development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090184 positive regulation of kidney development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030315 T-tubule
GO:0031965 nuclear membrane
GO:0045121 membrane raft
Protein Structure and Domains
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR002175 Endothelin receptor A
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
Post-translational Modifications
SwissProt P25101
PhosphoSite PhosphoSite-P25101
UniProt Splice Variant
Entrez Gene 1909
UniGene Hs.183713
RefSeq NP_001948
OMIM 131243
HPRD 00571
EMBL AC093908 AF014826 AK304451 AK312812 AK315931 AY275462 AY422989 BC022511 CH471056 D11151 D90348 L06622 S45956 S55772 S57498 S63938 S67127 S81539 S81542 S81545 X61950
GenPept AAA58447 AAB20278 AAB20407 AAB23644 AAB25212 AAB25530 AAB36325 AAB36326 AAB36327 AAB94859 AAH22511 AAP32294 AAQ87880 BAA01920 BAA14359 BAG35670 BAG65268 BAH14302 CAA43953 EAX05019 EAX05021