InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EDNRA

Summary

InnateDB Gene

IDBG-40278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDNRA

Gene Name

endothelin receptor type A

Synonyms

ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR

Species

Homo sapiens

Ensembl Gene

ENSG00000151617

Encoded Proteins

IDBP-40280

endothelin receptor type A

IDBP-40282

endothelin receptor type A

IDBP-477690

endothelin receptor type A

IDBP-482826

endothelin receptor type A

IDBP-478164

endothelin receptor type A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:147480917-147544954

Strand

Forward strand

Band

q31.22

Transcripts

ENST00000324300	ENSP00000315011
ENST00000358556	ENSP00000351359
ENST00000511804	ENSP00000425354
ENST00000510697	ENSP00000427259
ENST00000506066	ENSP00000425281
ENST00000514245
ENST00000503721

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0001934	positive regulation of protein phosphorylation
GO:0003094	glomerular filtration
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007507	heart development
GO:0007568	aging
GO:0007585	respiratory gaseous exchange
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014032	neural crest cell development
GO:0014070	response to organic cyclic compound
GO:0014824	artery smooth muscle contraction
GO:0015758	glucose transport
GO:0019233	sensory perception of pain
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0042310	vasoconstriction
GO:0042482	positive regulation of odontogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043084	penile erection
GO:0043278	response to morphine
GO:0048144	fibroblast proliferation
GO:0048484	enteric nervous system development
GO:0048659	smooth muscle cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport
GO:0060137	maternal process involved in parturition
GO:0060322	head development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0090184	positive regulation of kidney development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0031965	nuclear membrane
GO:0045121	membrane raft