InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGEF3

Summary

InnateDB Protein

IDBP-40924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF3

Protein Name

Rho guanine nucleotide exchange factor (GEF) 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296315

InnateDB Gene

IDBG-40920 (ARHGEF3)

Protein Structure

UniProt Annotation

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269PubMed:12221096}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. {ECO:0000269PubMed:10873612, ECO:0000269PubMed:12221096}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway